The 21st Pennsylvania Cavalry Regiment lost 4 officers and 80 enlisted men killed and mortally wounded and 2 officers and 116 enlisted men by disease during the Civil War.

1863
June 28-August 1 Organized at Harrisburg and Chambersburg for six months service
August 1 Company B at Gettysburg, Pa.Companies C, E, H, K, L & M, duty at Pottsville, Pa., and Scranton, Pa.
August 23 Companies A, D, F, G and I ordered to Harper’s Ferry. Attached to Cavalry Brigade, 1st Division, Dept. West Virginia
November 15-18 Expedition from Charlestown to New Market (Detachment)
November 16 Mount Jackson
December 10-21 Wells’ demonstration from Harper’s Ferry
1864
January 3 Skirmish at Winchester
February 20 Mustered out
February Reorganized at Harrisburg
April 1 Company D detached and duty at Scranton, Pa., entire term.
May 15 Regiment moved to Washington, D. C.
June 1 Joined Army Potomac in the field at Cold Harbor, Va. Attached to 2nd Brigade, 1st Division, 5th Army Corps, Army of the Potomac
June 1-12 Battles about Cold Harbor, Va.
June 16-18 Before Petersburg
June 16 to April 2 Siege operations against Petersburg and Richmond
August 18-21 Weldon Railroad
September Attached to 1st Brigade, 1st Division, 5th Corps
September 29-October 2 Poplar Springs Church
October 5 Sent to City Point and mounted. Attached to 3rd Brigade, 2nd Division, Cavalry Corps, Army Potomac
October 27-28 Boydton Plank Road, Hatcher’s Run
December 7-12 Warren’s Expedition to Hicksford
December 9-10 Bellefield
1865
February 5-7 Dabney’s Mills, Hatcher’s Run
March Attached to 2nd Brigade, 2nd Division, Cavalry Corps
March 28-April 9 Appomattox Campaign
March 30-31 Dinwiddie C. H.
April 1 Five Forks
April 5 Paine’s Cross Road
April 6 Sailor’s Creek
April 9
Appomattox Court House

Surrender of Lee and his army.

April 23-29 Expedition to Danville
May-June Moved to Lynchburg, Va., and duty there and in Dept. of Virginia
July 8 Mustered out