The 161st Ohio Infantry Regiment lost 1 enlisted man killed and 1 officer and 12 enlisted men to disease during the Civil War.

1864
Organized at Camp Chase, Ohio
May 9 Mustered in under Colonel Oliver P. Taylor and left State for Cumberland, Md. Attached to Reserve Division, Dept. of West Virginia.
May 28 Moved to Martinsburg, W. Va. and assigned to 1st Brigade, 1st Division, West Virginia.
June 4 Five companies detached and assigned to duty in charge of supply trains for Hunter’s Army.
June 6-25 Hunter’s Raid on Lynchburg
June 19-25 Retreat to Martinsburg
June 28 Moved to Beverly guarding train of 150 wagon, wounded, and 150 prisoners.
June 30 Continued o Webster
July 2 To Martinsburg bt rail.
July 4-7 Operations about Harper’s Ferry
July 6-7 Defense of Maryland Heights
July-August Duty in the Defenses of Maryland Heights
September 2 Ordered home and mustered out at Camp Chase under Colonel Taylor